Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.34 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969991 | 0.86 | JAK3 (0.36) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL13883460 | 0.85 | BACE1 (0.40) | CDK1JAK2JAK3LTA4H | |
| SCHEMBL3973959 | 0.81 | JAK3 (0.38) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL3969959 | 0.81 | JAK3 (0.38) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL3974063 | 0.80 | JAK3 (0.40) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL3969296 | 0.79 | BACE1 (0.40) | CDK1JAK2JAK3LTA4H | |
| SCHEMBL3974132 | 0.77 | JAK3 (0.43) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL3976981 | 0.75 | PRKCQ (0.44) | CDK1CDK2CDK7CDK5JAK2 | |
| SCHEMBL3971424 | 0.74 | TTK (0.56) | JAK2JAK3BTK | |
| SCHEMBL3966481 | 0.73 | BACE1 (0.48) | JAK2JAK3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |