Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 15/20 | 0.57 |
| ▸ | DRD2 | P14416 | 9/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 12/20 | 0.53 |
| ▸ | HTR1A | P08908 | 11/20 | 0.53 |
| ▸ | HTR2C | P28335 | 7/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973175 | 0.89 | DRD3 (0.55) | DRD3DRD2ADRA1AHTR2AHTR1A | |
| SCHEMBL3981785 | 0.89 | DRD2 (0.62) | DRD3DRD2ADRA1AHTR2AHTR1A | |
| SCHEMBL3984452 | 0.86 | DRD3 (0.62) | DRD3DRD2HTR2AHTR1AHTR2C | |
| SCHEMBL3974266 | 0.86 | HTR2A (0.49) | DRD3DRD2HTR2AHTR1AHTR2C | |
| SCHEMBL3974263 | 0.85 | HTR2A (0.49) | DRD3DRD2HTR2AHTR1AHTR2C | |
| SCHEMBL3976402 | 0.83 | DRD2 (0.56) | DRD3DRD2ADRA1AHTR2AHTR1A | |
| SCHEMBL8231965 | 0.81 | DRD4 (0.57) | DRD3DRD2HTR2AHTR1AHTR2C | |
| SCHEMBL3982334 | 0.80 | DRD2 (0.59) | DRD3DRD2ADRA1AHTR2AHTR1A | |
| SCHEMBL3982374 | 0.79 | DRD3 (0.52) | DRD3DRD2ADRA1AHTR2AHTR1A | |
| SCHEMBL3976554 | 0.78 | DRD3 (0.58) | DRD3DRD2ADRA1AHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |