Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974266 | 0.92 | HTR2A (0.49) | HTR2AHTR2CHTR7HTR1AHTR6 | |
| SCHEMBL3981781 | 0.89 | DRD2 (0.50) | HTR2AHTR2CHTR7HTR1ASIGMAR1 | |
| SCHEMBL3974264 | 0.85 | DRD3 (0.57) | HTR2AHTR2CHTR7HTR1AHTR6 | |
| SCHEMBL3973174 | 0.84 | KCNH2 (0.49) | HTR2AHTR7HTR1ASIGMAR1DRD2 | |
| SCHEMBL3976400 | 0.83 | ALDH1A1 (0.50) | HTR7TSHRLMNADRD2GAA | |
| SCHEMBL3973177 | 0.81 | KCNH2 (0.48) | HTR2AHTR2CHTR1ADRD2DRD3 | |
| SCHEMBL3981786 | 0.81 | SIGMAR1 (0.52) | HTR2AHTR2CHTR7HTR1ASIGMAR1 | |
| SCHEMBL3982331 | 0.79 | HTR1A (0.51) | HTR2AHTR7HTR1AHTR6SIGMAR1 | |
| SCHEMBL3209296 | 0.78 | SIGMAR1 (0.63) | HTR2AHTR7HTR1ASIGMAR1TSHR | |
| SCHEMBL3974512 | 0.78 | MAPT (0.42) | HTR2AHTR7HTR1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |