Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13270519 | 0.87 | TP53 (0.52) | PTPN11TP53RARBWDR5S1PR3 | |
| SCHEMBL2429973 | 0.87 | NNMT (0.41) | LMNAMAPTKMT2ARARBALDH1A1 | |
| SCHEMBL13299048 | 0.82 | TP53 (0.48) | PTPN11TP53RARBPLA2G4B | |
| SCHEMBL18133789 | 0.81 | PTPN11 (0.58) | PTPN11TP53S1PR3TSHRPLA2G4B | |
| SCHEMBL26454606 | 0.79 | RXRA (0.47) | ADRA2AOPRK1PTPN11TP53RARB | |
| SCHEMBL2424366 | 0.79 | ALDH1A1 (0.50) | CYP3A4ALDH1A1HPGD | |
| SCHEMBL8167721 | 0.79 | PTPN11 (0.61) | PTPN11TP53S1PR3TSHRPLA2G4B | |
| Hydrochloric Acid SCHEMBL9038246 | 0.77 | PTPN11 (0.60) | PTPN11TP53S1PR3TSHRPLA2G4B | |
| SCHEMBL10539639 | 0.77 | PTPN11 (0.64) | PTPN11TP53RARBS1PR3TSHR | |
| Hydrochloric Acid SCHEMBL8154036 | 0.77 | PTPN11 (0.60) | PTPN11TP53S1PR3TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |