Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975011 | 0.78 | EGLN1 (0.43) | EGLN1LMNATSHRHTTALDH1A1 | |
| SCHEMBL1758872 | 0.73 | BCHE (0.46) | HPGDMAPTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL1507742 | 0.72 | RAB9A (0.55) | EGLN1LMNAMAPK1CYP3A4MEN1 | |
| SCHEMBL1813245 | 0.71 | EGLN1 (0.44) | EGLN1LMNATSHRHTTALDH1A1 | |
| SCHEMBL1814575 | 0.71 | EGLN1 (0.44) | EGLN1LMNATSHRHTTALDH1A1 | |
| SCHEMBL12472139 | 0.71 | EGLN1 (0.61) | EGLN1LMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL1637949 | 0.71 | MAPK1 (0.46) | LMNATSHRHTTALDH1A1HPGD | |
| SCHEMBL14649475 | 0.70 | CYP3A4 (0.47) | EGLN1LMNATSHRHTTALDH1A1 | |
| SCHEMBL21801714 | 0.69 | BRD4 (0.53) | EGLN1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL17541529 | 0.69 | MMP2 (0.52) | LMNATSHRHTTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056823-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | Wyeth (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008024922-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | WYETH (US) | 2008-02-28 | — | — | WO | disclosed |