Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OXER1 | Q8TDS5 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978577 | 0.92 | OXER1 (0.43) | NPC1MAPTALDH1A1SMN1; SMN2BCL2 | |
| SCHEMBL3973747 | 0.85 | KMT2A (0.44) | NPC1MAPTALDH1A1SMN1; SMN2BCL2 | |
| SCHEMBL3990809 | 0.74 | CNR2 (0.60) | CNR1CNR2 | |
| SCHEMBL3972624 | 0.73 | POLB (0.55) | NPC1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3973488 | 0.73 | NR4A2 (0.51) | ALDH1A1SMN1; SMN2L3MBTL1KMT2ACNR1 | |
| SCHEMBL29920927 | 0.71 | EGFR (0.60) | NPC1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4685271 | 0.70 | EGFR (0.49) | NPC1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3975404 | 0.69 | CREBBP (0.45) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL3993831 | 0.68 | NTRK1 (0.42) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL5240303 | 0.68 | KDM4E (0.63) | MAPTALDH1A1SMN1; SMN2L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050237-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050237-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |