Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29920927 | 0.83 | EGFR (0.60) | EGFROXER1SMN1; SMN2L3MBTL1PTGDR2 | |
| SCHEMBL8451044 | 0.82 | USP14 (0.51) | L3MBTL1ALDH1A1ATM | |
| SCHEMBL1998148 | 0.80 | HTR6 (0.46) | EGFRALDH1A1HTTATMSRC | |
| SCHEMBL5240303 | 0.79 | KDM4E (0.63) | SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8702816 | 0.79 | KMT2A (0.62) | EGFRL3MBTL1ALDH1A1MAPTHTT | |
| SCHEMBL2001294 | 0.77 | KDM4E (0.49) | ALDH1A1MAPT | |
| SCHEMBL1993318 | 0.76 | CNR2 (0.55) | — | |
| SCHEMBL7958788 | 0.76 | NPY1R (0.62) | SMN1; SMN2L3MBTL1NPC1ALDH1A1MAPT | |
| SCHEMBL15667319 | 0.76 | ALDH1A1 (0.67) | EGFRSMN1; SMN2L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL2033920 | 0.76 | MEN1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569901-B1 | ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH CORP (US) | 2008-10-15 | — | — | EP | disclosed |