Sugi Predict

Sugi Predict / Compounds / SCHEMBL3975376

SCHEMBL3975376

SCHEMBL3975376

NNC(=O)c1c(C(=O)OC(=O)c2occc2-c2cccc(OCCc3ccccc3)c2)ccc(O)c1[N+](=O)[O-]

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ NR1H4 Q96RI1 1/20 0.38
▸ SIRT2 Q8IXJ6 1/20 0.35
▸ PPARG P37231 1/20 0.35
▸ GCGR P47871 1/20 0.35
▸ CYP19A1 P11511 1/20 0.34
▸ CYP11B1 P15538 1/20 0.34
▸ CYP11B2 P19099 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ PLA2G10 O15496 1/20 0.33
▸ PLA2G2A P14555 1/20 0.33
▸ MAOA P21397 1/20 0.33
▸ MAOB P27338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3982850 0.94 CTSV (0.37) NR1H4GCGRLMNASMN1; SMN2MAOB
SCHEMBL3976897 0.91 GCGR (0.40) NR1H4GCGRKDM4EALDH1A1LMNA
SCHEMBL3973173 0.90 GCGR (0.41) NR1H4GCGRKDM4EALDH1A1LMNA
SCHEMBL3982877 0.89 GCGR (0.40) NR1H4GCGRKDM4EALDH1A1LMNA
SCHEMBL3977971 0.89 NR1H4 (0.33) NR1H4GCGRKDM4EALDH1A1LMNA
SCHEMBL3976527 0.89 GCGR (0.40) NR1H4GCGRKDM4EALDH1A1LMNA
SCHEMBL3978234 0.89 ACMSD (0.37) GCGRPLA2G10PLA2G2A
SCHEMBL3979851 0.88 MEN1 (0.34) NR1H4SIRT2GCGRSMN1; SMN2
SCHEMBL3978025 0.88 MAOB (0.37) NR1H4GCGRMAOAMAOB
SCHEMBL3981998 0.88 GCGR (0.37) GCGRKDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7514452-B2 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same DAINIPPON PHARMACEUTICAL CO., LTD (JP) 2009-04-07 — — US claimed
US-20050171196-A1 2-Furancarboxylic acid hydrazides and pharmaceutical compositions containing the same DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2005-08-04 — — US claimed
EP-1489077-A1 2-FURANCARBOXYLIC ACID HYDRAZIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2004-12-22 — — EP claimed
US-7514452-B2 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same DAINIPPON PHARMACEUTICAL CO., LTD (JP) 2009-04-07 — — US disclosed
US-20050171196-A1 2-Furancarboxylic acid hydrazides and pharmaceutical compositions containing the same DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2005-08-04 — — US disclosed
EP-1489077-A1 2-FURANCARBOXYLIC ACID HYDRAZIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2004-12-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050171196-A1 2-Furancarboxylic acid hydrazides and pharmaceutical compositions containing the same GLP1R, GCGR, GPR119 NR1H4 288/4885SIRT2 210/4885PPARG 155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.