Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.81 |
| ▸ | INSR | P06213 | 3/20 | 0.81 |
| ▸ | KDR | P35968 | 2/20 | 0.81 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.81 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.81 |
| ▸ | LATS1 | O95835 | 1/20 | 0.81 |
| ▸ | LCK | P06239 | 1/20 | 0.81 |
| ▸ | LYN | P07948 | 1/20 | 0.81 |
| ▸ | RET | P07949 | 1/20 | 0.81 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.81 |
| ▸ | MET | P08581 | 1/20 | 0.81 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.81 |
| ▸ | INSRR | P14616 | 1/20 | 0.81 |
| ▸ | FECH | P22830 | 1/20 | 0.81 |
| ▸ | MARK3 | P27448 | 1/20 | 0.81 |
| ▸ | FLT4 | P35916 | 1/20 | 0.81 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.81 |
| ▸ | FLT3 | P36888 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13448066 | 0.92 | IGF1R (0.82) | IGF1RINSRKDRMAPK3MAPK1 | |
| Linsitinib SCHEMBL1758871 | 0.90 | IGF1R (0.92) | IGF1RINSRKDRMAPK3MAPK1 | |
| SCHEMBL14319786 | 0.90 | IGF1R (0.85) | IGF1RINSRKDRMAPK3MAPK1 | |
| SCHEMBL10225384 | 0.90 | IGF1R (0.79) | IGF1RINSRKDRMAPK3MAPK1 | |
| SCHEMBL400466 | 0.90 | IGF1R (0.65) | IGF1RINSRKDRMAPK3MAPK1 | |
| Linsitinib SCHEMBL400735 | 0.90 | IGF1R (1.00) | IGF1RINSRKDRMAPK3MAPK1 | |
| Linsitinib SCHEMBL10255925 | 0.90 | IGF1R (1.00) | IGF1RINSRKDRMAPK3MAPK1 | |
| Linsitinib SCHEMBL29392484 | 0.90 | IGF1R (1.00) | IGF1RINSRKDRMAPK3MAPK1 | |
| Linsitinib SCHEMBL400369 | 0.90 | IGF1R (1.00) | IGF1RINSRKDRMAPK3MAPK1 | |
| Linsitinib SCHEMBL400734 | 0.90 | IGF1R (1.00) | IGF1RINSRKDRMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |
| CN-102924458-B | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC | 2014-11-05 | — | — | CN | disclosed |
| US-8735405-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-05-27 | — | — | US | disclosed |
| US-8735405-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-05-27 | — | — | US | disclosed |
| US-8735405-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-05-27 | — | — | US | disclosed |
| US-8653268-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-02-18 | — | — | US | disclosed |
| US-8653268-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-02-18 | — | — | US | disclosed |
| US-8575164-B2 | Combination cancer therapy | OSI Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575164-B2 | Combination cancer therapy | OSI Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-20080267957-A1 | Combination cancer therapy | OSI PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | disclosed |
| US-20080267957-A1 | Combination cancer therapy | OSI PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | OSI PHARMACEUTICALS, INC. | 2008-01-17 | — | — | US | disclosed |
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | OSI PHARMACEUTICALS, INC. | 2008-01-17 | — | — | US | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| CN-1960993-A | 6, 6-bicyclic substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC (US) | 2007-05-09 | — | — | CN | disclosed |
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | ACERTA PHARMA B.V. (NL) | 2006-10-19 | — | — | US | disclosed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | IGF1R, IGFBP6, CDK6 | IGF1R 1/4885INSR 104/4885KDR 958/4885 |
| US-20080267957-A1 | Combination cancer therapy | IGF1R, IGFBP4, IGFBP1 | IGF1R 1/4885INSR 10/4885KDR 583/4885 |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | IGF1R, MAP2K7, BRCA1 | IGF1R 1/4885INSR 27/4885KDR 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.