Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL327274 | 0.83 | CDK4 (0.51) | TRPM8GPR52MGAMGAASI | |
| SCHEMBL9955315 | 0.81 | TRPM8 (0.44) | TRPM8GPR52MGAMGAASI | |
| SCHEMBL8084192 | 0.81 | MAPT (0.51) | TRPM8GPR52KDM4EMEN1MAPT | |
| SCHEMBL2632548 | 0.78 | CA12 (0.42) | TRPM8GPR52MGAMGAASI | |
| SCHEMBL13201797 | 0.78 | F2RL3 (0.50) | TRPM8GPR52KDM4EMEN1MAPT | |
| SCHEMBL7948630 | 0.76 | GPR52 (0.39) | TRPM8GPR52MGAMGAASI | |
| SCHEMBL12991810 | 0.76 | PIK3CG (0.62) | — | |
| SCHEMBL16806021 | 0.75 | TRPM8 (0.51) | TRPM8KDM4EMAPT | |
| SCHEMBL15702664 | 0.72 | GAA (0.61) | GAAKDM4EMEN1MAPTKMT2A | |
| SCHEMBL9628693 | 0.71 | TRPM8 (0.65) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |