Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | DBH | P09172 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960065 | 0.73 | MEN1 (0.49) | HPGDALDH1A1DBHMEN1KMT2A | |
| SCHEMBL8336583 | 0.71 | CYP19A1 (0.68) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6529174 | 0.70 | ALDH1A1 (0.47) | GAAALDH1A1DBHMAPTLMNA | |
| SCHEMBL10444030 | 0.70 | CYP2C19 (0.51) | ALDH1A1MEN1KMT2AMAPTSIGMAR1 | |
| SCHEMBL6530474 | 0.69 | ALDH1A1 (0.43) | GAAIDO1ALDH1A1DBHMEN1 | |
| SCHEMBL27595895 | 0.67 | ALDH1A1 (0.63) | GAAIDO1ALDH1A1DBHCHRM2 | |
| SCHEMBL17820 | 0.67 | IDO1 (0.57) | GAAHPGDIDO1ALDH1A1CHRM2 | |
| SCHEMBL26654 | 0.67 | IDO1 (0.69) | GAAIDO1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL31290863 | 0.67 | IDO1 (0.69) | GAAIDO1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL10607688 | 0.67 | IDO1 (0.69) | GAAIDO1ALDH1A1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |