Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346651 | 0.81 | MAPT (0.73) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28464045 | 0.80 | ALDH1A1 (1.00) | MAPTKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL1542810 | 0.80 | RAB9A (0.64) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| Methyl Alcohol SCHEMBL27776732 | 0.79 | ALDH1A1 (0.97) | MAPTKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL7066252 | 0.79 | ALDH1A1 (0.72) | MAPTKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL10977555 | 0.78 | SMN1; SMN2 (0.70) | MAPTKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL10977586 | 0.78 | SMN1; SMN2 (0.70) | MAPTKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL10703240 | 0.77 | MAPT (0.67) | MAPTKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL25228303 | 0.77 | RAB9A (1.00) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14386135 | 0.77 | MEN1 (0.81) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053448-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009053448-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |