Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883738 | 1.00 | GAA (0.47) | GAAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL3968490 | 0.86 | POLB (0.53) | GAAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL3973576 | 0.85 | MAPT (0.50) | GAAPOLBMAPTALDH1A1RAB9A | |
| SCHEMBL13883742 | 0.85 | MAPT (0.50) | GAAPOLBMAPTALDH1A1RAB9A | |
| SCHEMBL3968489 | 0.80 | POLB (0.47) | GAAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL3974184 | 0.75 | POLB (0.50) | GAAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL3973159 | 0.72 | POLB (0.47) | GAAPOLBTSHRMAPTALDH1A1 | |
| SCHEMBL3973189 | 0.71 | POLB (0.55) | GAAPOLBTSHRMAPTRAB9A | |
| SCHEMBL31556376 | 0.71 | POLB (0.55) | GAAPOLBTSHRMAPTRAB9A | |
| SCHEMBL30158930 | 0.71 | FGFR1 (0.71) | GAAPOLBTSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |