Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971172 | 0.92 | PTAFR (0.48) | PTAFRNPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL13883896 | 0.87 | POLB (0.38) | PTAFRNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL3973159 | 0.82 | POLB (0.47) | RAB9APOLBGAATSHRKMT2A | |
| SCHEMBL13883750 | 0.82 | ABCB1 (0.42) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL3974184 | 0.80 | POLB (0.50) | RAB9APOLBGAATSHRKMT2A | |
| SCHEMBL3976494 | 0.79 | NPC1 (0.52) | PTAFRNPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL13883788 | 0.78 | PTAFR (0.40) | PTAFRSMN1; SMN2MAPTTBXAS1HPGD | |
| SCHEMBL13883740 | 0.78 | NPC1 (0.48) | PTAFRNPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL3968489 | 0.76 | POLB (0.47) | POLBGAATSHRLMNAKMT2A | |
| SCHEMBL3969866 | 0.76 | NAMPT (0.47) | NPC1RAB9APOLBGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |