Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971172 | 0.81 | PTAFR (0.48) | HPGDLMNANPC1RAB9AKMT2A | |
| SCHEMBL13883788 | 0.81 | PTAFR (0.40) | ROCK1ALDH1A1HPGDMAPT | |
| SCHEMBL13883746 | 0.80 | MTNR1A (0.52) | MTNR1BMTNR1AROCK1ALDH1A1NPC1 | |
| SCHEMBL13883896 | 0.76 | POLB (0.38) | MTNR1BMTNR1AROCK1ALDH1A1HPGD | |
| SCHEMBL3976475 | 0.76 | PTAFR (0.45) | HPGDLMNANPC1RAB9AKMT2A | |
| SCHEMBL3973159 | 0.73 | POLB (0.47) | MTNR1BMTNR1AROCK1ALDH1A1HPGD | |
| SCHEMBL4321178 | 0.71 | LMNA (0.51) | NAMPTALDH1A1HPGDLMNANPC1 | |
| SCHEMBL3974184 | 0.70 | POLB (0.50) | MTNR1BMTNR1AROCK1ALDH1A1HPGD | |
| SCHEMBL13913239 | 0.69 | NAMPT (0.70) | NAMPTALDH1A1HPGDLMNANPC1 | |
| SCHEMBL3971256 | 0.69 | NPC1 (0.47) | MTNR1BMTNR1AALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |