Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975109 | 0.85 | NPY5R (0.32) | NPY5RALDH1A1CYP1A2CYP3A4MAPT | |
| SCHEMBL3970810 | 0.78 | AKT1 (0.32) | ALDH1A1 | |
| SCHEMBL3971304 | 0.77 | ALOX5AP (0.42) | — | |
| SCHEMBL2973860 | 0.77 | HSD11B1 (0.31) | — | |
| SCHEMBL3970455 | 0.77 | ELOVL1 (0.35) | NPY5RNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL3907137 | 0.76 | PDE2A (0.32) | NPC1RAB9A | |
| SCHEMBL3977568 | 0.75 | HSD11B1 (0.33) | NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3973792 | 0.75 | HDAC4 (0.36) | NPY5R | |
| SCHEMBL3970704 | 0.74 | HSD11B1 (0.33) | NPY5RNPC1RAB9AMAPT | |
| SCHEMBL3972108 | 0.74 | HSD11B1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |