Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981976 | 0.87 | DRD2 (0.46) | SIGMAR1KCNH2HTR1ADRD2HTR7 | |
| SCHEMBL3977444 | 0.85 | DRD2 (0.52) | KCNH2HTR1ADRD2HTR7HTR2A | |
| SCHEMBL3982931 | 0.84 | HTR1A (0.47) | KCNH2HTR1ADRD2HTR7HTR2A | |
| SCHEMBL3976612 | 0.83 | DRD2 (0.48) | HTR1ADRD2HTR7HTR2AHTR6 | |
| SCHEMBL3980717 | 0.83 | POLB (0.42) | KCNH2HTR1ADRD2HTR7HTR2A | |
| SCHEMBL3981973 | 0.79 | DRD2 (0.46) | SIGMAR1KCNH2HTR1ADRD2HTR7 | |
| SCHEMBL3977439 | 0.78 | HTR1A (0.45) | SIGMAR1KCNH2HTR1ADRD2HTR7 | |
| SCHEMBL3982189 | 0.77 | DRD2 (0.44) | HTR1ADRD2HTR2ACACNA1GDRD4 | |
| SCHEMBL3187471 | 0.77 | CYP2D6 (0.57) | SIGMAR1KCNH2HTR1ADRD2HTR7 | |
| SCHEMBL3982437 | 0.77 | DRD2 (0.56) | KCNH2HTR1ADRD2HTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | claimed |