Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.48 |
| ▸ | HTR2A | P28223 | 7/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 12/20 | 0.47 |
| ▸ | DRD4 | P21917 | 7/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976607 | 0.92 | DRD2 (0.48) | DRD2HTR2AMCHR1HTR1AHTR2B | |
| SCHEMBL3982189 | 0.85 | DRD2 (0.44) | DRD2HTR2AHTR1ADRD3DRD4 | |
| SCHEMBL3976609 | 0.85 | DRD3 (0.60) | DRD2HTR2AHTR1AHTR2BDRD3 | |
| SCHEMBL3977448 | 0.83 | SIGMAR1 (0.45) | DRD2HTR2AHTR1AHTR7HTR6 | |
| SCHEMBL3981976 | 0.82 | DRD2 (0.46) | DRD2HTR2AHTR1AHTR7HTR6 | |
| SCHEMBL3982931 | 0.80 | HTR1A (0.47) | DRD2HTR2AHTR1AHTR7HTR6 | |
| SCHEMBL3980717 | 0.79 | POLB (0.42) | DRD2HTR2AHTR1AHTR7HTR6 | |
| SCHEMBL13484896 | 0.78 | DRD3 (0.58) | DRD2HTR2AHTR1AHTR2BDRD3 | |
| SCHEMBL13484925 | 0.77 | DRD3 (0.66) | DRD2HTR2AHTR1AHTR2BDRD3 | |
| SCHEMBL3982185 | 0.77 | CACNA1G (0.42) | DRD2HTR2AHTR1ADRD4ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | claimed |