Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166304 | 0.95 | HSD11B1 (0.61) | HSD11B1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3638448 | 0.92 | HSD11B1 (0.56) | HSD11B1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL22875343 | 0.86 | HSD11B1 (0.63) | HSD11B1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3501319 | 0.84 | HSD11B1 (0.61) | HSD11B1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12460079 | 0.84 | MGLL (0.57) | L3MBTL1MGLL | |
| SCHEMBL10195735 | 0.84 | KMT2A (0.65) | HSD11B1ALDH1A1MEN1KMT2AMGLL | |
| SCHEMBL3459209 | 0.83 | ACHE (0.65) | HSD11B1MEN1KMT2AL3MBTL1MGLL | |
| SCHEMBL13952158 | 0.82 | HSD11B1 (0.54) | HSD11B1MEN1KMT2AMGLLHTR2B | |
| SCHEMBL23094515 | 0.82 | KDM4E (0.55) | KDM4EMEN1KMT2APOLBGAA | |
| SCHEMBL8161198 | 0.82 | HSD11B1 (0.51) | HSD11B1ALDH1A1MEN1KMT2AMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060030-A1 | HETEROARYL-SUBSTITUTED 2-PYRIDINYLMETHYLAMINE DERIVATIVES | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2009-05-14 | — | — | WO | disclosed |
| EP-2058306-A1 | Heteroaryl-substituted 2-pyridinyl-methylamine derivatives | SCHWARZ PHARMA AG (DE) | 2009-05-13 | — | — | EP | disclosed |