Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | GHSR | Q92847 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975084 | 0.87 | MAPT (0.41) | RORCGHSRMAPTSLC6A4SLC6A2 | |
| SCHEMBL3997957 | 0.85 | TACR1 (0.39) | RORCMAPTTACR1SLC6A4SLC6A2 | |
| SCHEMBL4004209 | 0.79 | TACR1 (0.38) | RORCTACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3971153 | 0.76 | SLC6A4 (0.52) | TACR1SLC6A4SLC6A2SLC6A3S1PR1 | |
| SCHEMBL3997842 | 0.76 | PTK2 (0.37) | RORCMAPTTACR1SLC6A4SLC6A2 | |
| SCHEMBL4701211 | 0.75 | SLC6A4 (0.44) | TACR1SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL3977977 | 0.74 | SSTR5 (0.38) | TACR1SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL3998910 | 0.74 | REN (0.43) | MAPTSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4706328 | 0.74 | SLC6A4 (0.44) | TACR1SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4003258 | 0.74 | SLC6A2 (0.37) | MAPTTACR1SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |