Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11793308 | 0.89 | KDR (0.68) | KDRMAPTLMNAGAARAB9A | |
| SCHEMBL3973967 | 0.87 | KDR (0.66) | KDRMAPTLMNAGAARAB9A | |
| SCHEMBL618575 | 0.86 | KDR (0.82) | KDRPDK1TRPV1HDAC1HDAC8 | |
| SCHEMBL6055167 | 0.86 | LMNA (0.70) | KDRMAPTLMNAGAARAB9A | |
| SCHEMBL14972641 | 0.86 | PTGS1 (0.66) | PTGS1MAPTLMNARAB9AMEN1 | |
| SCHEMBL25143905 | 0.86 | PTGS1 (0.66) | PTGS1MAPTLMNAGAARAB9A | |
| SCHEMBL16367720 | 0.86 | PTGS1 (0.66) | PTGS1MAPTLMNAGAARAB9A | |
| SCHEMBL10184841 | 0.85 | KDR (0.59) | KDRMAPTLMNAGAARAB9A | |
| SCHEMBL24203611 | 0.85 | PTGS1 (0.61) | PTGS1MAPTLMNARAB9AGRM4 | |
| SCHEMBL28389908 | 0.84 | KDR (0.61) | KDRMAPTLMNAGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054004-A2 | PROCESS FOR THE PREPARATION OF SORAFENIB | NATCO PHARMA LIMITED (IN) | 2009-04-30 | — | — | WO | disclosed |