SCHEMBL6055167

SCHEMBL6055167

O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)c1ccccc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.70
MAPT P10636 3/20 0.70
MEN1 O00255 2/20 0.70
KMT2A Q03164 2/20 0.70
GRM4 Q14833 1/20 0.69
RAB9A P51151 4/20 0.69
GAA P10253 2/20 0.69
NPC1 O15118 3/20 0.68
KDR P35968 1/20 0.68
HTT P42858 1/20 0.64
NPSR1 Q6W5P4 1/20 0.64
PDK1 Q15118 1/20 0.61
KCNK3 O14649 1/20 0.60
KCNK9 Q9NPC2 1/20 0.60
TMPRSS4 Q9NRS4 1/20 0.60
KCNJ5 P48544 1/20 0.60
KCNJ3 P48549 1/20 0.60
P2RX1 P51575 1/20 0.57
CASR P41180 1/20 0.57
TRPV1 Q8NER1 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11793308 0.88 KDR (0.68) LMNAMAPTMEN1KMT2AGRM4
SCHEMBL3973967 0.87 KDR (0.66) LMNAMAPTMEN1KMT2AGRM4
SCHEMBL7745875 0.86 MAPT (0.76) LMNAMAPTMEN1KMT2ARAB9A
SCHEMBL5631971 0.86 LMNA (0.70) LMNAMAPTMEN1KMT2AGRM4
SCHEMBL3977997 0.86 KDR (0.64) LMNAMAPTMEN1KMT2AGRM4
SCHEMBL3644090 0.85 LMNA (0.58) LMNAMAPTMEN1KMT2AGRM4
SCHEMBL16780086 0.85 LMNA (0.69) LMNAMAPTMEN1KMT2AGRM4
SCHEMBL13576966 0.85 KDR (0.67) LMNAMAPTMEN1KMT2ARAB9A
SCHEMBL12835410 0.85 GRM4 (0.64) LMNAMAPTMEN1KMT2AGRM4
SCHEMBL14082250 0.84 GRM4 (0.71) LMNAMAPTGRM4RAB9AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1155278-A Arylthio compounds as antibacteral and antiviral agents WARNER LAMBERT CO (US) 1997-07-23 CN claimed
EP-1682181-A2 COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT Novartis AG (CH) 2006-07-26 EP disclosed
EP-1572686-A1 ANTHRANILIC ACID AMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE Novartis AG (CH) 2005-09-14 EP disclosed
WO-2005027972-A2 COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT NOVARTIS AG (CH) 2005-03-31 WO disclosed
WO-2004052884-A1 ANTHRANILIC ACID AMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE NOVARTIS AG (CH) 2004-06-24 WO disclosed
EP-1129075-A1 N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS Novartis AG (CH) 2001-09-05 EP disclosed
WO-2000027820-A1 N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2000-05-18 WO disclosed
US-4275210-A IMMUNOSUPPRESSIVE AGENTS, ANTIFERTILITY AGENTS, PROPHYLAXIS OF MAREK'S DISEASE IN CHICKENS AND HERBICIDES ELI LILLY AND COMPANY (US) 1981-06-23 US disclosed
US-4088770-A ANTIFERTILITY, HERBICIDES ELI LILLY AND COMPANY (US) 1978-05-09 US disclosed