Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18930812 | 0.81 | HSD17B1 (0.52) | NPC1RAB9AKMT2AKDM4EMAPT | |
| SCHEMBL6424261 | 0.77 | HTT (0.40) | NPC1RAB9AKMT2ATP53CES2 | |
| SCHEMBL6420648 | 0.77 | HTT (0.43) | RAB9AKMT2AMAPTGAAPOLB | |
| SCHEMBL6429633 | 0.77 | HTT (0.59) | NPC1RAB9AKMT2AKDM4EMAPT | |
| SCHEMBL28904603 | 0.77 | CA1 (0.48) | NPC1RAB9AKMT2ACA1CA2 | |
| SCHEMBL22501255 | 0.77 | CA1 (0.53) | NPC1RAB9AKDM4ECA1CA2 | |
| SCHEMBL978334 | 0.77 | CA1 (0.50) | NPC1RAB9AKMT2AKDM4ECA1 | |
| SCHEMBL4598838 | 0.75 | GPR88 (0.48) | NPC1RAB9AKMT2AGAAALDH1A1 | |
| SCHEMBL19265536 | 0.75 | CNR2 (0.50) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL22251873 | 0.72 | CA1 (0.53) | NPC1RAB9AKMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057164-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008021781-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |