SCHEMBL3978646

SCHEMBL3978646

CC(C)(C)[Si](Oc1cccc(CC=O)c1)(c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
BCHE P06276 1/20 0.33
SQLE Q14534 1/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
CHRM2 P08172 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM3 P20309 2/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPK1 P28482 1/20 0.33
PPARG P37231 1/20 0.33
PPARA Q07869 1/20 0.33
CCNB2 O95067 1/20 0.33
CDK1 P06493 1/20 0.33
CDK4 P11802 1/20 0.33
CCNB1 P14635 1/20 0.33
CCND1 P24385 1/20 0.33
CCNB3 Q8WWL7 1/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4950223 0.81 CTBP2 (0.39) MAOBPPARGPPARAPDK1PDK2
SCHEMBL4521425 0.80 MAOA (0.47) MAOAMAOBMEN1KMT2AALDH1A1
SCHEMBL2761534 0.80 CA12 (0.42) CHRM2CHRM1CHRM3PPARGPPARA
SCHEMBL7221196 0.77 MAOA (0.45) MAOAPPARGPPARATAAR1
SCHEMBL25456702 0.77 CYSLTR2 (0.50) MAPK1PPARGPPARASMN1; SMN2
SCHEMBL704145 0.77 CA4 (0.37) ALDH1A1MAPK1SMN1; SMN2L3MBTL1
SCHEMBL7092637 0.76 CYP3A4 (0.42) ALDH1A1
SCHEMBL31637357 0.76 F2 (0.48) MEN1KMT2APPARGPPARA
SCHEMBL8135354 0.75
SCHEMBL4470099 0.75 MAOB (0.42) MAOBKMT2AALDH1A1MAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2056817-A1 BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM Bayer HealthCare AG (DE) 2009-05-13 EP disclosed
WO-2008025509-A1 BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-03-06 WO disclosed