Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28215751 | 0.98 | MAOA (0.53) | MAOAADRA2AADRA2CADRA1DADRA1A | |
| Acetic Acid SCHEMBL28215170 | 0.89 | KDM4E (0.42) | MAOATGFBR1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8708948 | 0.87 | MAOA (0.52) | MAOATGFBR1DYRK1APDE2APDE4A | |
| SCHEMBL4703000 | 0.84 | MAOA (0.41) | MAOAADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL9833682 | 0.84 | HPGD (0.46) | MAOASMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL9834352 | 0.81 | MAOA (0.42) | MAOASMN1; SMN2DYRK1APDE10AALDH1A1 | |
| SCHEMBL31284785 | 0.80 | GAK (0.38) | MAOAADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL12821066 | 0.80 | GAK (0.38) | MAOAADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL21186144 | 0.79 | TUBB4A (0.41) | MAOATGFBR1ALDH1A1 | |
| SCHEMBL10819312 | 0.79 | MAOA (0.52) | MAOAADRA2AADRA2CADRA1AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104557692-B | A kind of preparation method of pantoprazole intermediate 2- chloromethyls -3,4- dimethoxy pyridine hydrochlorides | 寿光富康制药有限公司 | 2018-08-21 | — | — | CN | claimed |
| CN-108191745-A | The preparation method of 2- methylol -3,4- dimethoxy-pyridines | 滁州学院 | 2018-06-22 | — | — | CN | claimed |
| CN-104557692-A | Preparation method of pantoprazole intermediate 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride | Shouguang fukang pharmaceutical co ltd | 2015-04-29 | — | — | CN | claimed |
| CN-101875629-B | Industrial preparation method of pantoprazole intermediate pyridine hydrochloride | NANJING YUANHUA TECHNOLOGY CONSULTATION CO LTD | 2013-03-06 | — | — | CN | claimed |
| CN-102304083-A | Preparation method of 2-chloromethyl-3,4-dimethoxypyridine hydrochloride | NANTONG CHENGXIN AMINO ACID CO LTD | 2012-01-04 | — | — | CN | claimed |
| CN-101875629-A | Industrial preparation method of pantoprazole intermediate pyridine hydrochloride | NANJING YUANHUA TECHNOLOGY CONSULTATION CO LTD | 2010-11-03 | — | — | CN | claimed |
| CN-101475561-A | Method for synthesizing pantoprazole and salt thereof | HAINAN MEIDA PHARMACEUTICAL CO (CN) | 2009-07-08 | — | — | CN | claimed |
| CN-104557692-B | A kind of preparation method of pantoprazole intermediate 2- chloromethyls -3,4- dimethoxy pyridine hydrochlorides | 寿光富康制药有限公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-108191745-A | The preparation method of 2- methylol -3,4- dimethoxy-pyridines | 滁州学院 | 2018-06-22 | — | — | CN | disclosed |
| US-20170218000-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. | 2017-08-03 | — | — | US | disclosed |
| EP-2870144-B1 | OREXIN RECEPTOR ANTAGONISTS | HEPTARES THERAPEUTICS LTD (GB) | 2017-04-19 | — | — | EP | disclosed |
| US-9273077-B2 | Phosphorus derivatives as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| CN-103483248-B | The synthetic method of the chloro-3-methoxyl group of a kind of 4--2-methyl-4-pyridine | JIANGSU YUXIANG CHEMICAL CO., LTD. (CN) | 2016-01-20 | — | — | CN | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0208452-B1 | PYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1991-09-18 | — | — | EP | disclosed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |
| CN-1032539-A | The Thienoimidazole derivatives that replaces, their preparation method contains their pharmaceutical preparation and they are as the application of gastric acid secretion inhibitor | HOECHST AG (DE) | 1989-04-26 | — | — | CN | disclosed |
| US-4738975-A | Pyridine derivatives, and use as anti-ulcer agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| CN-86104636-A | Produce the method for pyridine derivate | — | 1987-01-28 | — | — | CN | disclosed |
| EP-0208452-A2 | Pyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170218000-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | MAP3K6, PIK3CA, MAP3K20 | MAOA 4075/4885ADRA2A 4635/4885ADRA2C 4471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.