Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4981370 | 0.92 | MTNR1A (0.61) | MTNR1AMTNR1BHPGD | |
| SCHEMBL4999591 | 0.82 | MTNR1A (0.55) | MTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL4993152 | 0.82 | MTNR1A (0.55) | MTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL3982936 | 0.82 | MTNR1A (0.55) | MTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL4982213 | 0.82 | MTNR1A (0.55) | MTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL4980983 | 0.81 | MTNR1A (0.56) | MTNR1AMTNR1BHPGD | |
| SCHEMBL4983098 | 0.77 | SIRT2 (0.52) | MTNR1AMTNR1BHPGD | |
| SCHEMBL3973779 | 0.76 | NR1H4 (0.53) | MTNR1AMTNR1BCYP2D6PPARGPPARA | |
| SCHEMBL3982953 | 0.76 | NPC1 (0.54) | CYP2D6MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3397413 | 0.75 | MTNR1A (1.00) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056810-A2 | THIOUREA COMPOUNDS | National Health Research Institutes (TW) | 2009-05-13 | — | — | EP | disclosed |
| US-20080113975-A1 | THIOUREA COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-05-15 | — | — | US | disclosed |
| US-20080096875-A1 | THIOUREA COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-04-24 | — | — | US | disclosed |
| WO-2008022204-A2 | THIOUREA COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096875-A1 | THIOUREA COMPOUNDS | TPMT, HAVCR2, ETV6 | MTNR1A 4535/4885MTNR1B 3855/4885CYP2D6 491/4885 |
| US-20080113975-A1 | THIOUREA COMPOUNDS | TPMT, HAVCR2, EIF2AK2 | MTNR1A 4383/4885MTNR1B 3688/4885CYP2D6 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.