Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982647 | 0.97 | POLB (0.49) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL3983329 | 0.90 | DRD3 (0.49) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL3979490 | 0.89 | DRD2 (0.50) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL3979475 | 0.88 | POLB (0.52) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL3976526 | 0.87 | DRD3 (0.51) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL3976533 | 0.85 | DRD2 (0.55) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL3976988 | 0.85 | HTR1A (0.50) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL3978392 | 0.82 | DRD3 (0.57) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL13484926 | 0.82 | HTR1A (0.58) | POLBDRD3HTR1AHTR2ADRD2 | |
| SCHEMBL13484931 | 0.82 | HTR7 (0.49) | POLBDRD3HTR1AHTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |