Sugi Predict

Sugi Predict / Compounds / SCHEMBL398000

SCHEMBL398000

SCHEMBL398000

Cc1ccc(S(=O)(=O)Nc2ccccc2N)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.70
▸ CYP2C9 P11712 2/20 0.70
▸ CYP2C19 P33261 2/20 0.70
▸ ALDH1A1 P00352 2/20 0.70
▸ USP2 O75604 1/20 0.70
▸ POLB P06746 1/20 0.70
▸ MAPT P10636 1/20 0.70
▸ NOD2 Q9HC29 1/20 0.70
▸ L3MBTL1 Q9Y468 1/20 0.70
▸ KEAP1 Q14145 1/20 0.65
▸ NFE2L2 Q16236 1/20 0.65
▸ CA2 P00918 3/20 0.64
▸ CA9 Q16790 3/20 0.64
▸ CA1 P00915 2/20 0.64
▸ CA4 P22748 1/20 0.64
▸ CA7 P43166 1/20 0.64
▸ CA12 O43570 2/20 0.62
▸ MCOLN3 Q8TDD5 1/20 0.62
▸ TSHR P16473 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL27511346 0.91 LMNA (0.58) LMNACYP2C9CYP2C19ALDH1A1USP2
SCHEMBL11456845 0.89 LMNA (0.64) LMNACYP2C9CYP2C19ALDH1A1USP2
SCHEMBL19451108 0.87 LMNA (0.82) LMNACYP2C9CYP2C19ALDH1A1USP2
SCHEMBL2068526 0.87 LMNA (0.82) LMNACYP2C9CYP2C19ALDH1A1USP2
SCHEMBL2068236 0.85 ALDH1A1 (0.58) ALDH1A1MAPTKEAP1CA2CA9
SCHEMBL30737452 0.85 ALDH1A1 (0.58) ALDH1A1MAPTKEAP1CA2CA9
SCHEMBL11785265 0.84 LMNA (0.77) LMNACYP2C9CYP2C19ALDH1A1USP2
Hydrochloric Acid SCHEMBL29885455 0.84 ALDH1A1 (0.56) ALDH1A1MAPTKEAP1CA2CA9
SCHEMBL28508946 0.83 ALDH1A1 (0.61) LMNACYP2C9CYP2C19ALDH1A1USP2
SCHEMBL7579730 0.83 APP (0.82) LMNACYP2C9CYP2C19ALDH1A1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114931961-B Hydroformylation catalyst and application thereof 万华化学集团股份有限公司 2024-02-27 — — CN disclosed
CN-117510460-A Benzo [ b ] thiophene derivative containing sulfonamide unit, and preparation method and application thereof 贵州大学 2024-02-06 — — CN disclosed
CN-114931961-A Hydroformylation catalyst and application thereof 万华化学集团股份有限公司 2022-08-23 — — CN disclosed
EP-3705477-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS Vertex Pharmaceuticals Incorporated (US) 2020-09-09 — — EP disclosed
US-10662192-B2 Modulators of ATP-binding cassette transporters VERTEX PHARMACEUTICALS INCORPORATED (US) 2020-05-26 — — US disclosed
EP-3216787-B1 INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMA (US) 2020-02-19 — — EP disclosed
US-20190144450-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2019-05-16 — — US disclosed
EP-3216787-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS Vertex Pharmaceuticals Incorporated (US) 2017-09-13 — — EP disclosed
EP-2502911-B1 Modulators of ATP-binding cassette transporters VERTEX PHARMA (US) 2017-04-05 — — EP disclosed
US-20160318931-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2016-11-03 — — US disclosed
EP-0990645-B1 NOVEL SULFONAMIDE DERIVATIVES NIPPON KAYAKU KK (JP) 2004-07-28 — — EP disclosed
US-6458960-B1 ANTICANCER AGENTS, RHEUMATIC DISEASES AND ANTIINFLAMMATORY AGENTS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2002-10-01 — — US disclosed
US-6180796-B1 TUBULIN POLYMERIZATION INHIBITORS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2001-01-30 — — US disclosed
EP-0990645-A1 NOVEL SULFONAMIDE DERIVATIVES Nippon Kayaku Kabushiki Kaisha (JP) 2000-04-05 — — EP disclosed
US-5003052-A Monoazo fiber reactive dye for cellulose, polyamides, wool, silk, polyurethanes and leather CIBA-GEIGY CORPORATION (US) 1991-03-26 — — US disclosed
US-4417059-A COLOR FORMERS FOR CARBONLESS DUPLICATING AND THERMAL MARKING STERLING DRUG INC. (US) 1983-11-22 — — US disclosed
EP-0018939-B1 1:2 METAL COMPLEX DYESTUFFS OF AZOMETHINES, PROCESS FOR THEIR PREPARATION AND PROCESS FOR DYEING AND PRINTING BY USING THESE DYESTUFFS CIBA-GEIGY AG (CH) 1983-10-05 — — EP disclosed
US-4343493-A LEUCO DYES; CARBON-FREE; PRESSURE SENSITIVE ELEMENTS; THERMOSENSITIVITY STERLING DRUG INC. (US) 1982-08-10 — — US disclosed
US-4315854-A Chromium and cobalt complex amino hydroxy azomethine dyes CIBA-GEIGY CORPORATION (US) 1982-02-16 — — US disclosed
EP-0018939-A1 1:2 Metal complex dyestuffs of azomethines, process for their preparation and process for dyeing and printing by using these dyestuffs CIBA-GEIGY AG (CH) 1980-11-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190144450-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 LMNA 2816/4885CYP2C9 2728/4885CYP2C19 3102/4885
US-10662192-B2 Modulators of ATP-binding cassette transporters CFTR, ABCB1, ABCC2 LMNA 2816/4885CYP2C9 2728/4885CYP2C19 3102/4885
US-20160318931-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 LMNA 2816/4885CYP2C9 2728/4885CYP2C19 3102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.