Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | GUSB | P08236 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830001 | 0.99 | L3MBTL1 (0.55) | L3MBTL1NPC1GUSBMAPTLMNA | |
| SCHEMBL4826429 | 0.82 | TSHR (0.68) | NPC1GUSBMAPTLMNAHTT | |
| SCHEMBL4825454 | 0.81 | L3MBTL1 (0.58) | L3MBTL1NPC1GUSBMAPTLMNA | |
| SCHEMBL4828176 | 0.81 | L3MBTL1 (0.58) | L3MBTL1NPC1GUSBMAPTLMNA | |
| Hydrochloric Acid SCHEMBL3976391 | 0.81 | LMNA (0.68) | L3MBTL1NPC1LMNAHTTKDM4E | |
| SCHEMBL13845816 | 0.81 | L3MBTL1 (0.54) | L3MBTL1NPC1GUSBMAPTLMNA | |
| SCHEMBL4633311 | 0.79 | TSHR (0.67) | L3MBTL1NPC1GUSBMAPTLMNA | |
| SCHEMBL10032067 | 0.79 | NPC1 (0.71) | L3MBTL1NPC1GUSBMAPTLMNA | |
| SCHEMBL15101603 | 0.77 | LMNA (0.73) | L3MBTL1NPC1GUSBMAPTLMNA | |
| SCHEMBL31673809 | 0.77 | LMNA (0.73) | L3MBTL1NPC1GUSBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063364-A2 | MODULATORS OF UROTENSIN RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009053895-A2 | QUINOLINE UROTENSIN-II RECEPTOR ANTAGONISTS | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-04-30 | — | — | WO | disclosed |