Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 20/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | BCR | P11274 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255604 | 0.92 | SRC (0.76) | SRCABL1BCR | |
| SCHEMBL5254228 | 0.92 | SRC (0.76) | SRCABL1BCR | |
| SCHEMBL4078986 | 0.92 | SRC (0.75) | SRCABL1BCR | |
| SCHEMBL5256228 | 0.91 | SRC (0.69) | SRCABL1BCR | |
| SCHEMBL28748059 | 0.91 | SRC (0.76) | SRCABL1BCR | |
| SCHEMBL7014678 | 0.89 | SRC (0.69) | SRCABL1BCR | |
| SCHEMBL5255444 | 0.88 | SRC (0.77) | SRCABL1BCR | |
| SCHEMBL5253427 | 0.88 | SRC (0.75) | SRCABL1BCR | |
| SCHEMBL6183535 | 0.88 | SRC (0.75) | SRCABL1BCR | |
| SCHEMBL4967200 | 0.86 | SRC (0.84) | SRCABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981505-A4 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | WYETH CORP (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20090099356-A1 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | WYETH (US) | 2009-04-16 | — | — | US | disclosed |
| EP-1981505-A2 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | Wyeth a Corporation of the State of Delaware (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20080033175-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | WYETH HOLDINGS CORPORATION (US) | 2008-02-07 | — | — | US | disclosed |
| US-7297795-B2 | Process for preparation of 4-amino-3-quinolinecarbonitriles | WYETH HOLDINGS CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2007092153-A2 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |
| EP-1660453-A2 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-QUINOLINECARBONITRILES | Wyeth Holdings Corporation (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019201-A2 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-QUINOLINECARBONITRILES | WYETH HOLDINGS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20050043537-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | WYETH HOLDINGS CORPORATION (US) | 2005-02-24 | — | — | US | disclosed |
| US-20040176602-A1 | 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | WYETH | 2004-09-09 | — | — | US | disclosed |
| US-6689772-B1 | ANTINEOPLASTIC AGENTS; OSTEOPOROSIS; POLYCYSTIC KIDNEY DISEASE; ANTIVIRAL AGENTS | WYETH | 2004-02-10 | — | — | US | disclosed |
| US-6521618-B2 | Antineoplastic agents, agents for treatment of osteoporosis and polycystic kidney disease | WYETH | 2003-02-18 | — | — | US | disclosed |
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020026052-A1 | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-02-28 | — | — | US | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176602-A1 | 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | PKD1, PKD2, CSNK1A1 | SRC 237/4885ABL1 126/4885BCR 647/4885 |
| US-20080033175-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | BTF3, PTMS, BCAT2 | SRC 1820/4885ABL1 147/4885BCR 1121/4885 |
| US-20050043537-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | BTF3, PTMS, BCAT2 | SRC 1820/4885ABL1 147/4885BCR 1121/4885 |
| US-20020026052-A1 | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | PKD1, PKD2, CSNK1A1 | SRC 237/4885ABL1 126/4885BCR 647/4885 |
| US-20090099356-A1 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | PARK7, UQCRB, PRMT7 | SRC 3605/4885ABL1 64/4885BCR 1453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.