Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.59 |
| ▸ | MMP12 | P39900 | 12/20 | 0.59 |
| ▸ | MMP8 | P22894 | 11/20 | 0.59 |
| ▸ | MMP13 | P45452 | 11/20 | 0.59 |
| ▸ | MMP14 | P50281 | 11/20 | 0.59 |
| ▸ | MMP16 | P51512 | 11/20 | 0.59 |
| ▸ | MMP9 | P14780 | 11/20 | 0.59 |
| ▸ | MMP3 | P08254 | 8/20 | 0.59 |
| ▸ | MMP1 | P03956 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129486 | 0.80 | PKM (0.73) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL10672859 | 0.80 | HTT (0.73) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL15423745 | 0.80 | PKM (0.73) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL17472319 | 0.79 | PKM (0.86) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL18069681 | 0.79 | PKM (0.86) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL14148915 | 0.79 | PKM (0.86) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL19008825 | 0.79 | PKM (0.86) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL314725 | 0.78 | MMP2 (0.74) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL17368152 | 0.77 | PKM (0.58) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL15074660 | 0.77 | PKM (0.58) | MMP2MMP12MMP8MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009545556-A | — | — | 2009-12-24 | — | — | JP | claimed |
| EP-2059500-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | Bracco Imaging S.p.A (IT) | 2009-05-20 | — | — | EP | claimed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | claimed |