Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 8/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.39 |
| ▸ | PIK3R5 | Q8WYR1 | 8/20 | 0.39 |
| ▸ | PIK3R3 | Q92569 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982265 | 0.93 | PARP1 (0.36) | PIK3CDPIK3CAPIK3CBPIK3R2PIK3CG | |
| SCHEMBL3985369 | 0.93 | LMNA (0.36) | AVPR1BPARP1MAPTTSHRALDH1A1 | |
| SCHEMBL3985842 | 0.91 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBPIK3R2PIK3CG | |
| SCHEMBL3981550 | 0.91 | PIK3CD (0.33) | PIK3CDPIK3CAPIK3CBPIK3R2PIK3CG | |
| SCHEMBL3985220 | 0.90 | PARP1 (0.41) | PARP1MAPTTSHRALDH1A1 | |
| SCHEMBL3987232 | 0.89 | PTGER4 (0.35) | PIK3CAAVPR1BCNR2 | |
| SCHEMBL1387060 | 0.88 | ALDH1A1 (0.36) | CYP3A4CYP2C19GAAPARP1MAPT | |
| SCHEMBL3988126 | 0.88 | PTGER4 (0.34) | PIK3CDPIK3CAPIK3CBAVPR1BCNR2 | |
| SCHEMBL3982488 | 0.86 | PTGER4 (0.33) | PIK3CDPIK3CAPIK3CBPIK3CGAVPR1B | |
| SCHEMBL3984446 | 0.86 | PTGER4 (0.37) | PIK3CAAVPR1BCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538112-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-05-26 | — | — | US | claimed |
| US-20080287394-A1 | Hiv Integrase Inhibitors | MERCK & CO., INC. (US) | 2008-11-20 | — | — | US | claimed |
| EP-1756114-B1 | HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME (US) | 2014-11-19 | — | — | EP | disclosed |
| US-7538112-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20080287394-A1 | Hiv Integrase Inhibitors | MERCK & CO., INC. (US) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287394-A1 | Hiv Integrase Inhibitors | DHPS, DPYD, TYMP | PIK3CD 252/4885PIK3CA 98/4885PIK3CB 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.