Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 9/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979936 | 0.97 | POLB (0.32) | CES2CES1EPHX1KDM4EPOLB | |
| SCHEMBL3983190 | 0.92 | MEN1 (0.33) | NPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL2437352 | 0.75 | EPHX1 (0.34) | CES2CES1EPHX1 | |
| SCHEMBL7980877 | 0.74 | EPHX1 (0.52) | CES2CES1EPHX1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11593530 | 0.74 | EPHX1 (0.52) | CES2CES1EPHX1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1462698 | 0.74 | EPHX1 (0.52) | CES2CES1EPHX1SMN1; SMN2L3MBTL1 | |
| SCHEMBL121265 | 0.74 | EPHX1 (0.52) | CES2CES1EPHX1SMN1; SMN2L3MBTL1 | |
| SCHEMBL10874421 | 0.74 | EPHX1 (0.52) | CES2CES1EPHX1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1463411 | 0.74 | EPHX1 (0.52) | CES2CES1EPHX1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3987567 | 0.73 | NPC1 (0.33) | NPC1RAB9AKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562575-B1 | FUSED CYCLOALKYL AMIDES AND ACIDS AND THEIR THERAPEUTIC APPLICATIONS FOR THE TREATMENT OF I.A. EPILEPSY | ABBOTT LAB (US) | 2009-05-20 | — | — | EP | claimed |