Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | GMNN | O75496 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.31 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983190 | 0.80 | MEN1 (0.33) | NPC1RAB9ANPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL3979936 | 0.75 | POLB (0.32) | L3MBTL1KDM4E | |
| SCHEMBL3990121 | 0.75 | ALDH1A1 (0.36) | NPC1RAB9ANPSR1L3MBTL1MAPT | |
| SCHEMBL5076651 | 0.74 | POLB (0.33) | TDP1 | |
| SCHEMBL3983989 | 0.73 | CES2 (0.36) | NPC1RAB9AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL3984368 | 0.71 | LMNA (0.33) | LMNA | |
| SCHEMBL3984100 | 0.71 | POLB (0.43) | L3MBTL1GMNNALDH1A1LMNATDP1 | |
| SCHEMBL3981109 | 0.71 | POLB (0.43) | L3MBTL1GMNNALDH1A1LMNATDP1 | |
| SCHEMBL12096020 | 0.69 | MEN1 (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL2426612 | 0.69 | SERPINE1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562575-B1 | FUSED CYCLOALKYL AMIDES AND ACIDS AND THEIR THERAPEUTIC APPLICATIONS FOR THE TREATMENT OF I.A. EPILEPSY | ABBOTT LAB (US) | 2009-05-20 | — | — | EP | claimed |