Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 8/20 | 0.38 |
| ▸ | MOK | Q9UQ07 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992722 | 0.86 | MOK (0.43) | PIK3CDPIK3CBPIK3CACYP3A4NPC1 | |
| SCHEMBL3988815 | 0.80 | MOK (0.42) | PIK3CDPIK3CBPIK3CAJAK3JAK2 | |
| SCHEMBL3990070 | 0.80 | JAK2 (0.41) | PIK3CDPIK3CBPIK3CAJAK3CYP3A4 | |
| SCHEMBL3987449 | 0.80 | JAK2 (0.46) | PIK3CAJAK1JAK3JAK2MOK | |
| SCHEMBL3988357 | 0.80 | AKT1 (0.43) | PIK3CDPIK3CBPIK3CAJAK3JAK2 | |
| SCHEMBL3987968 | 0.79 | JAK2 (0.51) | PIK3CDPIK3CBPIK3CAJAK1JAK3 | |
| SCHEMBL3987596 | 0.79 | MOK (0.38) | PIK3CDPIK3CBPIK3CACYP3A4NPC1 | |
| SCHEMBL3987459 | 0.78 | JAK2 (0.41) | PIK3CDPIK3CBPIK3CAJAK1JAK3 | |
| SCHEMBL4527319 | 0.78 | PIK3CB (0.55) | PIK3CDPIK3CBPIK3CAALDH1A1MAPT | |
| SCHEMBL3985383 | 0.77 | HPGDS (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061784-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-27 | — | — | EP | claimed |
| WO-2008032086-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |