Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MGMT | P16455 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31617176 | 0.73 | HRH1 (0.38) | MAOAMAOBHRH1L3MBTL1MGMT | |
| SCHEMBL3984810 | 0.68 | L3MBTL1 (0.40) | MAOAMAOBHRH1L3MBTL1MGMT | |
| SCHEMBL29452029 | 0.65 | MAOA (0.50) | MAOAMAOBHRH1L3MBTL1LMNA | |
| SCHEMBL7915833 | 0.65 | MAOA (0.50) | MAOAMAOBHRH1L3MBTL1LMNA | |
| SCHEMBL20069016 | 0.63 | SLC6A4 (0.44) | MAOAMAOBHRH1L3MBTL1LMNA | |
| SCHEMBL28270390 | 0.62 | HRH1 (0.44) | MAOAMAOBHRH1L3MBTL1LMNA | |
| SCHEMBL21940865 | 0.61 | HRH4 (0.41) | HRH1ATAD2LMNA | |
| SCHEMBL23500896 | 0.60 | HRH1 (0.39) | MAOAMAOBHRH1L3MBTL1MGMT | |
| SCHEMBL29375684 | 0.59 | — | — | |
| SCHEMBL10672099 | 0.59 | HRH1 (0.67) | MAOAMAOBHRH1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063240-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF AURORA KINASE | ARROW THERAPEUTICS LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |