SCHEMBL3985376

SCHEMBL3985376

C#CCCCCNCCc1cccc2ccccc12

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.48
MTNR1A P48039 2/20 0.46
NQO2 P16083 1/20 0.46
CA12 O43570 2/20 0.43
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CA4 P22748 2/20 0.43
CA9 Q16790 2/20 0.43
CA3 P07451 1/20 0.43
CA6 P23280 1/20 0.43
CA5A P35218 1/20 0.43
CA7 P43166 1/20 0.43
CA14 Q9ULX7 1/20 0.43
CA5B Q9Y2D0 1/20 0.43
SLC2A1 P11166 4/20 0.42
KMT2A Q03164 1/20 0.42
SIGMAR1 Q99720 1/20 0.40
CHRM2 P08172 1/20 0.38
SMPD1 P17405 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3987787 0.89 HPGD (0.51) HPGDMTNR1ANQO2CA12CA1
SCHEMBL8794788 0.82 HPGD (0.64) HPGDMTNR1ANQO2CA12CA1
SCHEMBL14544011 0.80 CA12 (0.59) HPGDMTNR1ANQO2CA12CA1
Hydrochloric Acid SCHEMBL3988569 0.80 NQO2 (0.53) HPGDMTNR1ANQO2CA12CA1
SCHEMBL28097582 0.79 CYP1A2 (0.48) MTNR1ANQO2
SCHEMBL4802023 0.79 SIGMAR1 (0.54) HPGDMTNR1ANQO2CA12CA1
SCHEMBL28360959 0.79 CA12 (0.65) HPGDMTNR1ANQO2CA12CA1
SCHEMBL16106842 0.78 MTNR1A (0.54) HPGDMTNR1ANQO2CA12CA1
SCHEMBL16106841 0.78 MTNR1A (0.54) HPGDMTNR1ANQO2CA12CA1
SCHEMBL9049841 0.77 SIGMAR1 (0.62) HPGDMTNR1AKMT2ASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2061449-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES Leo Pharma A/S (DK) 2009-05-27 EP claimed
WO-2008019690-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES LEO PHARMA A/S (DK) 2008-02-21 WO claimed
EP-2061449-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES Leo Pharma A/S (DK) 2009-05-27 EP disclosed
WO-2008019690-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES LEO PHARMA A/S (DK) 2008-02-21 WO disclosed