SCHEMBL3987787

SCHEMBL3987787

C#CCCNCCc1cccc2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.51
MTNR1A P48039 3/20 0.49
NQO2 P16083 1/20 0.49
SMPD1 P17405 1/20 0.43
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA4 P22748 1/20 0.41
CA9 Q16790 1/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 2/20 0.41
CYP2C9 P11712 1/20 0.41
SIGMAR1 Q99720 1/20 0.40
MAPK1 P28482 2/20 0.39
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MC5R P33032 1/20 0.39
MAOB P27338 1/20 0.39
CYP2D6 P10635 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3985376 0.89 HPGD (0.48) HPGDMTNR1ANQO2SMPD1CA12
SCHEMBL8794788 0.86 HPGD (0.64) HPGDMTNR1ANQO2SMPD1CA12
Hydrochloric Acid SCHEMBL3988569 0.84 NQO2 (0.53) HPGDMTNR1ANQO2SMPD1CA12
SCHEMBL28097582 0.83 CYP1A2 (0.48) MTNR1ANQO2CYP1A2CYP2C19CYP2C9
SCHEMBL13086096 0.78 MTNR1A (0.57) HPGDMTNR1ANQO2CA12CA1
SCHEMBL3992354 0.77 HPGD (0.58) HPGDMTNR1ANQO2SMPD1CA12
SCHEMBL8858591 0.76 NQO2 (0.58) HPGDMTNR1ANQO2SMPD1CA12
SCHEMBL16106841 0.75 MTNR1A (0.54) HPGDMTNR1ANQO2CA12CA1
SCHEMBL16106842 0.75 MTNR1A (0.54) HPGDMTNR1ANQO2CA12CA1
SCHEMBL3982326 0.75 HPGD (0.52) HPGDMTNR1ANQO2SMPD1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2061449-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES Leo Pharma A/S (DK) 2009-05-27 EP claimed
WO-2008019690-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES LEO PHARMA A/S (DK) 2008-02-21 WO claimed
EP-2061449-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES Leo Pharma A/S (DK) 2009-05-27 EP disclosed
WO-2008019690-A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES LEO PHARMA A/S (DK) 2008-02-21 WO disclosed