Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1240051 | 0.77 | S100A4 (0.42) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL1569377 | 0.75 | DYRK1A (0.56) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL29485719 | 0.75 | DYRK1A (0.56) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL13995259 | 0.75 | PGR (0.41) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL2484200 | 0.75 | S100A4 (0.41) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL2146997 | 0.75 | PGR (0.53) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL2484201 | 0.75 | S100A4 (0.41) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL2484202 | 0.75 | S100A4 (0.41) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| SCHEMBL17209482 | 0.73 | S100A4 (0.39) | S100A4SLC6A2SLC6A4SLC6A3PTPRC | |
| Hydrochloric Acid SCHEMBL7762692 | 0.73 | S100A4 (0.39) | S100A4SLC6A2SLC6A4SLC6A3PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861565-A2 | SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY | The Regents of The University of California (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013188750-A2 | SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-12-19 | — | — | WO | disclosed |
| EP-2066670-A2 | INTEGRASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2009067541-A2 | INTEGRASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2009-05-28 | — | — | WO | disclosed |
| EP-1907403-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007136714-A2 | INTEGRASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007009109-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-01-18 | — | — | WO | disclosed |