Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986848 | 0.89 | RAD52 (0.50) | MAPTGAASMN1; SMN2ALDH1A1RAD52 | |
| SCHEMBL3986791 | 0.80 | SIGMAR1 (0.40) | MAPTGAARAB9AALDH1A1HTT | |
| SCHEMBL3990362 | 0.79 | PKM (0.66) | MAPTGAASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3985472 | 0.78 | MAPT (0.51) | MAPTGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL16592515 | 0.77 | GAA (0.59) | MAPTGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6353701 | 0.77 | MAPT (0.59) | MAPTGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL2071884 | 0.77 | GAA (0.59) | MAPTGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3982267 | 0.77 | LMNA (0.38) | MAPTGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3979269 | 0.77 | HSD17B10 (0.47) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL10605578 | 0.75 | MAPT (0.57) | MAPTGAASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059511-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008025556-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | disclosed |