Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | PTPRB | P23467 | 1/20 | 0.53 |
| ▸ | PTPRE | P23469 | 1/20 | 0.53 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 6/20 | 0.49 |
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982699 | 0.88 | METAP2 (0.63) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL3982706 | 0.88 | PTPRC (0.53) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL3988437 | 0.88 | METAP2 (0.62) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL3982737 | 0.84 | ESR1 (0.53) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL3982513 | 0.79 | METAP2 (0.49) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL3982247 | 0.79 | PTPRC (0.49) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL2367735 | 0.78 | NR3C1 (0.60) | ESR1ALDH1A1CCR2ACLY | |
| SCHEMBL3985677 | 0.77 | METAP2 (0.82) | METAP2METAP1ALDH1A1CCR1CCR2 | |
| SCHEMBL3985804 | 0.76 | ACLY (0.52) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL3984731 | 0.75 | METAP2 (0.55) | PTPRCPTPN2PTPN1PTPRBPTPRE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491718-B2 | Sulfonamides having antiangiogenic and anticancer activity | ABBOTT LABORATORIES (US) | 2009-02-17 | — | — | US | disclosed |
| US-20040167128-A1 | Sulfonamides having antiangiogenic and anticancer activity | ABBVIE INC. | 2004-08-26 | — | — | US | disclosed |
| US-20040157836-A1 | Sulfonamides having antiangiogenic and anticancer activity | ABBOTT LABORATORIES | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167128-A1 | Sulfonamides having antiangiogenic and anticancer activity | METAP2, METAP1, DNPEP | PTPRC 2454/4885PTPN2 964/4885PTPN1 2479/4885 |
| US-20040157836-A1 | Sulfonamides having antiangiogenic and anticancer activity | METAP2, METAP1, DNPEP | PTPRC 2454/4885PTPN2 964/4885PTPN1 2479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.