Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751411 | 0.94 | MAPT (0.49) | MAPTHPGDMAPK1L3MBTL1DRD4 | |
| SCHEMBL7602449 | 0.84 | MAPT (0.51) | MAPTHPGDMAPK1L3MBTL1DRD4 | |
| SCHEMBL2799797 | 0.83 | MAPT (0.53) | MAPTHPGDMAPK1L3MBTL1KMT2A | |
| SCHEMBL2543486 | 0.80 | REN (0.49) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL832294 | 0.80 | DRD4 (0.52) | MAPK1L3MBTL1DRD4DRD2DRD3 | |
| SCHEMBL12601506 | 0.80 | REN (0.48) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL8165437 | 0.80 | MAPT (0.48) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL5795265 | 0.79 | MAPT (0.58) | MAPTHPGDMAPK1L3MBTL1DRD4 | |
| SCHEMBL10289213 | 0.78 | REN (0.50) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL3925202 | 0.78 | MAPT (0.47) | MAPTHPGDMAPK1L3MBTL1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097377-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008058387-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-05-22 | — | — | WO | disclosed |