Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | REN | P00797 | 6/20 | 0.50 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602449 | 0.87 | MAPT (0.51) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL1751411 | 0.84 | MAPT (0.49) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL12601506 | 0.83 | REN (0.48) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL8165437 | 0.83 | MAPT (0.48) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL8405334 | 0.82 | ALDH1A1 (0.47) | L3MBTL1KCNA3DRD2DRD4DRD3 | |
| SCHEMBL10289213 | 0.81 | REN (0.50) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL3925202 | 0.81 | MAPT (0.47) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL695344 | 0.81 | PKM (0.57) | MAPK1L3MBTL1PKMKDM4EALDH1A1 | |
| SCHEMBL663105 | 0.80 | REN (0.49) | MAPTHPGDMAPK1L3MBTL1REN | |
| SCHEMBL2547093 | 0.80 | REN (0.52) | MAPTHPGDMAPK1L3MBTL1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097377-B1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2010-07-07 | — | — | EP | disclosed |
| WO-2008058387-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-05-22 | — | — | WO | disclosed |
| WO-2006021403-A1 | BICYCLONONENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |