Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCK1 | P35558 | 14/20 | 0.78 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3983059 | 0.96 | PCK1 (0.72) | PCK1RXFP1PDE5AADORA2BADORA1 | |
| SCHEMBL3979856 | 0.89 | PCK1 (0.80) | PCK1RXFP1PDE5AADORA2B | |
| SCHEMBL3983066 | 0.88 | PCK1 (0.65) | PCK1ADORA2BADORA1 | |
| SCHEMBL3976945 | 0.88 | PCK1 (1.00) | PCK1RXFP1 | |
| Trifluoroacetic Acid SCHEMBL3981359 | 0.85 | PCK1 (0.74) | PCK1RXFP1PDE5AADORA2B | |
| SCHEMBL3978048 | 0.85 | PCK1 (0.94) | PCK1RXFP1 | |
| SCHEMBL3980809 | 0.84 | PCK1 (0.83) | PCK1RXFP1ADORA2B | |
| SCHEMBL3985137 | 0.83 | PCK1 (0.91) | PCK1RXFP1ADORA2B | |
| SCHEMBL3977758 | 0.82 | PCK1 (0.76) | PCK1RXFP1PDE5AADORA2BADORA1 | |
| SCHEMBL3981235 | 0.82 | PCK1 (0.83) | PCK1RXFP1PDE5AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515972-B1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | EP | disclosed |
| US-7135475-B2 | Antidiabetic agents | HOFFMANN-LA ROCHE INC. (US) | 2006-11-14 | — | — | US | disclosed |
| EP-1515972-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-23 | — | — | EP | disclosed |
| US-20040014766-A1 | Amide substituted xanthine derivatives | HOFFMANN-LA ROCHE INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003106459-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014766-A1 | Amide substituted xanthine derivatives | GYS2, GLS2, PYGL | PCK1 14/4885RXFP1 296/4885PDE5A 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.