Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375349 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| SCHEMBL14744099 | 0.81 | DPP7 (0.42) | GAAKMT2AMMP1MMP3MMP8 | |
| SCHEMBL14396537 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| SCHEMBL6165804 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| SCHEMBL5436113 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| SCHEMBL738198 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| SCHEMBL24322495 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| SCHEMBL3062998 | 0.78 | MMP1 (0.45) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| SCHEMBL3068967 | 0.78 | MMP1 (0.45) | SMN1; SMN2PKMCYP3A4CYP2C19GAA | |
| Hydrochloric Acid SCHEMBL318913 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP3A4CYP2C19GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971333-A4 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-05-20 | — | — | EP | disclosed |
| US-20090068718-A1 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | LIANG CONGXIN | 2009-03-12 | — | — | US | disclosed |
| US-20080269212-A1 | Amino acid derivatives of indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-10-30 | — | — | US | disclosed |
| EP-1971333-A2 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007081560-A2 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269212-A1 | Amino acid derivatives of indolinone based protein kinase inhibitors | PHKG1, MAP3K20, MKNK1 | SMN1; SMN2 4054/4885PKM 671/4885CYP3A4 4435/4885 |
| US-20090068718-A1 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | PHKG1, MAP3K20, MKNK1 | SMN1; SMN2 4054/4885PKM 671/4885CYP3A4 4435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.