Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 18/20 | 0.90 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.90 |
| ▸ | DRD2 | P14416 | 1/20 | 0.90 |
| ▸ | ADRA1D | P25100 | 16/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 16/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Snap-7941 SCHEMBL5658585 | 0.95 | ADRA1A (1.00) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL6712292 | 0.93 | ADRA1A (0.79) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL6710975 | 0.93 | ADRA1A (0.79) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL7091765 | 0.93 | ADRA1A (0.79) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL7093785 | 0.93 | ADRA1A (0.79) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL6713510 | 0.93 | ADRA1A (0.78) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL7096153 | 0.93 | ADRA1A (0.78) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL6718967 | 0.92 | ADRA1A (0.77) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL7096683 | 0.92 | ADRA1A (0.77) | ADRA1AMCHR1DRD2ADRA1DADRA1B | |
| SCHEMBL7092125 | 0.92 | ADRA1A (0.76) | ADRA1AMCHR1DRD2ADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531816-B1 | SPIROCYCLIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF | LUNDBECK & CO AS H (DK) | 2009-01-21 | — | — | EP | disclosed |
| US-7473698-B2 | Secondary amino anilinic piperidines as MCH1 antagonists and uses thereof | H. LUNBECK A/S (DK) | 2009-01-06 | — | — | US | disclosed |
| EP-1590326-A4 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | LUNDBECK & CO AS H (DK) | 2008-04-30 | — | — | EP | disclosed |
| US-7335665-B2 | Spirocyclic piperidines as MCH1 antagonists and uses thereof | H - LUNDBECK A/S (DK) | 2008-02-26 | — | — | US | disclosed |
| US-7199135-B2 | Substituted alkyl amido piperidines | H. LUNDBECK A/S (DK) | 2007-04-03 | — | — | US | disclosed |
| US-20070043080-A1 | Substituted anilinic piperidines as MCH selective antagonists | MARZABADI MOHAMMAD R | 2007-02-22 | — | — | US | disclosed |
| US-20060217418-A1 | Substituted alkyl amido piperidines | H. LUNDBECK A/S (DK) | 2006-09-28 | — | — | US | disclosed |
| US-7105544-B2 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2006-09-12 | — | — | US | disclosed |
| US-20060173027-A1 | Spirocvclic piperidines as mch1 antagonists and uses thereof | H. LUNDBECK A/S (DK) | 2006-08-03 | — | — | US | disclosed |
| US-7067534-B1 | Substituted anilinic piperidines as MCH selective antagonists | H. LUNDBECK A/S (DK) | 2006-06-27 | — | — | US | disclosed |
| US-20060084649-A9 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2006-04-20 | — | — | US | disclosed |
| US-20060041139-A9 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | H. LUNDBECK A/S (DK) | 2006-02-23 | — | — | US | disclosed |
| US-20050245743-A1 | Secondary amino anilinic piperidines as mch1 antagonists and uses thereof | H. LUNDBECK A/S (DK) | 2005-11-03 | — | — | US | disclosed |
| EP-1590326-A2 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | H. Lundbeck A/S (DK) | 2005-11-02 | — | — | EP | disclosed |
| US-20050154020-A1 | 4-Aryl piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2005-07-14 | — | — | US | disclosed |
| US-20040186103-A1 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-09-23 | — | — | US | disclosed |
| WO-2004064764-A2 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | H. LUNDBECK A/S (DK) | 2004-08-05 | — | — | WO | disclosed |
| US-20040073036-A1 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-15 | — | — | US | disclosed |
| US-20040038855-A1 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof | H. LUNDBECK A/S (DK) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245743-A1 | Secondary amino anilinic piperidines as mch1 antagonists and uses thereof | MCHR1, MCHR2, MC1R | ADRA1A 75/4885MCHR1 1/4885DRD2 40/4885 |
| US-20070043080-A1 | Substituted anilinic piperidines as MCH selective antagonists | MCHR1, MCHR2, MC1R | ADRA1A 46/4885MCHR1 1/4885DRD2 119/4885 |
| US-20040038855-A1 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof | MCHR1, MCHR2, MC1R | ADRA1A 88/4885MCHR1 1/4885DRD2 612/4885 |
| US-20040073036-A1 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | ADRA1A 54/4885MCHR1 1/4885DRD2 74/4885 |
| US-20060173027-A1 | Spirocvclic piperidines as mch1 antagonists and uses thereof | MCHR1, MCHR2, CRHR1 | ADRA1A 47/4885MCHR1 1/4885DRD2 77/4885 |
| US-20060084649-A9 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | ADRA1A 54/4885MCHR1 1/4885DRD2 74/4885 |
| US-20060041139-A9 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | MCHR1, MCHR2, MC1R | ADRA1A 54/4885MCHR1 1/4885DRD2 74/4885 |
| US-20060217418-A1 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | ADRA1A 54/4885MCHR1 1/4885DRD2 74/4885 |
| US-20050154020-A1 | 4-Aryl piperidines | MCHR1, MCHR2, MC1R | ADRA1A 39/4885MCHR1 1/4885DRD2 81/4885 |
| US-20040186103-A1 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | ADRA1A 54/4885MCHR1 1/4885DRD2 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.