SCHEMBL3986889

SCHEMBL3986889

O=C(CBr)CC(=O)Nc1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.55
KDM1A O60341 1/20 0.55
MAPT P10636 3/20 0.53
HDAC4 P56524 7/20 0.53
HDAC1 Q13547 7/20 0.53
HDAC7 Q8WUI4 7/20 0.53
HDAC11 Q96DB2 7/20 0.53
HDAC8 Q9BY41 7/20 0.53
HDAC6 Q9UBN7 7/20 0.53
HDAC9 Q9UKV0 7/20 0.53
HDAC5 Q9UQL6 7/20 0.53
HDAC3 O15379 6/20 0.53
HDAC2 Q92769 6/20 0.53
HDAC10 Q969S8 6/20 0.53
L3MBTL1 Q9Y468 2/20 0.52
HTT P42858 1/20 0.52
MAOB P27338 1/20 0.51
TP53 P04637 1/20 0.50
EPHX1 P07099 1/20 0.50
TSHR P16473 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27538195 0.87 EPHX2 (0.63) EPHX2KDM1AMAPTHDAC4HDAC1
SCHEMBL230627 0.85 HDAC4 (0.62) EPHX2KDM1AMAPTHDAC4HDAC1
SCHEMBL31112364 0.85 L3MBTL1 (0.53) EPHX2KDM1AMAPTHDAC4HDAC1
SCHEMBL1689206 0.83 EPHX2 (0.68) EPHX2KDM1AMAPTHDAC4HDAC1
SCHEMBL23088339 0.82 KMT2A (0.74) MAPTL3MBTL1HTTMAOBSMN1; SMN2
SCHEMBL10774471 0.82 HDAC4 (0.58) EPHX2KDM1AMAPTHDAC4HDAC1
SCHEMBL9001575 0.82 EPHX2 (0.57) EPHX2KDM1AMAPTHDAC4HDAC1
SCHEMBL6413259 0.81 GAA (0.58) MAPTHDAC1HDAC6HDAC3HDAC2
SCHEMBL6407780 0.81 KMT2A (0.56) MAPTL3MBTL1HTTTP53TSHR
SCHEMBL6414674 0.81 POLB (0.71) HDAC4HDAC1HDAC7HDAC11HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118420527-A Preparation method of 4-bromomethylquinolinone 山东洪方精细化工有限公司 2024-08-02 CN claimed
CN-116951958-A Automatic production system of 4-bromo-3-oxo-N-phenylbutyramide 江西邦浦医药化工有限公司 2023-10-27 CN claimed
CN-115073371-A Preparation method of 4-bromomethyl quinolinone 四川沃肯精细化工有限公司 2022-09-20 CN claimed
CN-112321444-A Synthesis method of 4-bromo-3-oxo-N-phenylbutanamide 江西邦浦医药化工有限公司 2021-02-05 CN claimed
CN-121298935-A Detection method of bromoacetoacetanilide and aniline in rebamipide tablet 浙江核力欣健药业有限公司 2026-01-09 CN disclosed
CN-121298935-A Detection method of bromoacetoacetanilide and aniline in rebamipide tablet 浙江核力欣健药业有限公司 2026-01-09 CN disclosed
CN-120776325-B Method for preparing acetoacetanilide by electrochemical selective debromination 天津海光科技发展股份有限公司 2025-11-21 CN disclosed
CN-120776325-A Method for preparing acetoacetanilide by electrochemical selective debromination 天津海光科技发展股份有限公司 2025-10-14 CN disclosed
CN-118420527-A Preparation method of 4-bromomethylquinolinone 山东洪方精细化工有限公司 2024-08-02 CN disclosed
CN-118420527-A Preparation method of 4-bromomethylquinolinone 山东洪方精细化工有限公司 2024-08-02 CN disclosed
US-20240158368-A1 Pyrrolidine Main Protease Inhibitors as Antiviral Agents ABBVIE INC. (US) 2024-05-16 US disclosed
WO-2024081351-A1 PYRROLIDINE MAIN PROTEASE INHIBITORS AS ANTIVIRAL AGENTS ABBVIE INC. (US) 2024-04-18 WO disclosed
US-4558158-A Process for the production of 4-(trialkylammonium)-acetoacetarylides LONZA LTD. (CH) 1985-12-10 US disclosed
US-4552983-A Process for the production of 4-(trialkylammonium)-acetoacetarylides LONZA LTD. (CH) 1985-11-12 US disclosed
US-4305833-A Lubricating oils containing acetoacetanilides as antioxidants UOP INC. (US) 1981-12-15 US disclosed
US-4243407-A 2-Acylaminothiazol-4-ylacetamides as post emergent selective herbicides GULF OIL CORPORATION (US) 1981-01-06 US disclosed
US-4232163-A 2-Acylaminothiazol-4-ylacetamides as post emergent selective herbicides GULF OIL CORPORATION (US) 1980-11-04 US disclosed
US-4152329-A 2-ACYLAMINOTHIAZOL-4-YLACETAMIDES AS POST-EMERGENT SELECTIVE HERBICIDES GULF OIL CORPORATION (US) 1979-05-01 US disclosed
US-4120690-A 2-Acylaminothiazol-4-ylacetamides as post-emergent selective herbicides GULF OIL CORPORATION (US) 1978-10-17 US disclosed
US-3969406-A Process for the production of carnitine LONZA LTD. (CH) 1976-07-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158368-A1 Pyrrolidine Main Protease Inhibitors as Antiviral Agents PREP, PEPD, DNPEP EPHX2 4229/4885KDM1A 1142/4885MAPT 1993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.