Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6032429 | 0.86 | HCAR2 (0.81) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL18510324 | 0.85 | NPC1 (0.80) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL8689332 | 0.85 | HCAR2 (1.00) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL8943790 | 0.85 | HCAR2 (0.79) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL5696427 | 0.84 | HCAR2 (0.78) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL5696407 | 0.83 | HCAR2 (0.76) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL417809 | 0.83 | HCAR2 (0.71) | HCAR2MEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL4914608 | 0.83 | HCAR2 (0.76) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL4915695 | 0.83 | HCAR2 (0.76) | HCAR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL4912964 | 0.83 | NPC1 (0.80) | HCAR2MEN1KMT2ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057110-A1 | GPR109A AGONISTS FOR THE TREATMENT OF CEREBRAL ISCHEMIA | RUPRECHT-KARLS-UNIVERSITAT-HEIDELBERG (DE) | 2011-05-12 | — | — | WO | disclosed |
| EP-2062578-A1 | Novel use of chemical compounds for the treatment of AIDS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-05-27 | — | — | EP | disclosed |
| WO-2009063412-A1 | USE OF CHEMICAL COMPOUNDS FOR THE TREATMENT OF AIDS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-05-22 | — | — | WO | disclosed |