Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 12/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38703 | 0.85 | WDR5 (0.44) | WDR5KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL12664676 | 0.70 | PIK3CA (0.60) | PIK3CGRIPK1CYP1A2HPGDCYP2C19 | |
| SCHEMBL44576 | 0.70 | WDR5 (0.46) | WDR5KDM4EALDH1A1 | |
| SCHEMBL39537 | 0.70 | WDR5 (0.46) | WDR5KDM4EALDH1A1HPGD | |
| SCHEMBL13905159 | 0.69 | PIK3CG (0.53) | PIK3CGKDM4EALDH1A1TTKRIPK1 | |
| SCHEMBL12926171 | 0.68 | CSNK1D (0.40) | PIK3CGKDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL44694 | 0.67 | ALDH1A3 (0.50) | ALDH1A1CYP1A2CYP2C19RAB9A | |
| SCHEMBL44301 | 0.67 | WDR5 (0.66) | WDR5KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL46407 | 0.67 | CYP3A4 (0.42) | PIK3CGKDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL12664419 | 0.67 | PIK3CA (0.47) | PIK3CGRIPK1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |