Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 9/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | PRKX | P51817 | 1/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844942 | 0.87 | WDR5 (0.52) | WDR5CYP3A4ROCK2CYP2D6CYP2C9 | |
| SCHEMBL44512 | 0.87 | WDR5 (0.52) | WDR5GAACHRM3NPC1KDM4E | |
| SCHEMBL44576 | 0.85 | WDR5 (0.46) | WDR5AURKAKDM4EALDH1A1 | |
| SCHEMBL44216 | 0.82 | WDR5 (0.52) | WDR5AURKANPC1RAB9AHPGD | |
| SCHEMBL39537 | 0.82 | WDR5 (0.46) | WDR5KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL38703 | 0.82 | WDR5 (0.44) | WDR5ROCK2CYP2C9ROCK1AURKA | |
| SCHEMBL19997605 | 0.79 | WDR5 (1.00) | WDR5 | |
| SCHEMBL44653 | 0.79 | ALDH1A1 (0.54) | WDR5GAACYP3A4KDM4EALDH1A1 | |
| SCHEMBL12951391 | 0.78 | WDR5 (0.41) | WDR5GAACYP3A4ROCK2CYP2D6 | |
| SCHEMBL13844884 | 0.78 | WDR5 (0.41) | WDR5GAACYP3A4ROCK2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |